Inhibitors of PI3K/AKT/mTOR Signaling Pathway as a Novel Targeted Therapy for Cancer

There are various cytoplasmic cross talking signaling pathways possible in the target cell. The phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway (PI3K/AKT/mTOR pathway) plays a pivotal role in the pathophysiology of cancer. mTOR is a serine/threonine protein kinase involve in the downstream of the PI3K signaling pathway