Research Article
Published On: February 12, 2018

Boiling is an Efficient Way to Purify Recombinant Allergen Lit v 1 from Whiteleg Shrimp (Litopenaeus vannamei)

Wen Li$, Minying Li$, He Lai* and Ailin Tao*
Background: The whiteleg shrimp (Litopenaeus vannamei) allergen protein Lit v 1 is tropomyosin with a double-stranded alpha-helical coiled-coil structure, which is so stable that the native structure can be easily restored even after heating. Methods: Recombinant Lit v 1 was expressed in Escherichia coli (E. coli) and E. coli were lysed by ultra sonication or boiling....

Research Article
Published On: February 13, 2018

Novel Mannosylated Synthetic Saponin as Vaccine Adjuvant for Recombinant Japanese Encephalitis Antigen

M.C. Preethi Pallavi, Debabrata Bhunia, Srinivasa Reddy B, Vemireddy Sravanthi, Halmuthur M. Sampath Kumar*
A novel mannosylated trisaccharide based synthetic saponin, bearing a trisaccharide cluster linked to olanaldehyde was used as vaccine adjuvant. The novel saponin glycolipid was found to be nonhemolytic as compared to QS 21. The effectiveness of the synthesized molecule in terms of targeting dendritic cells was confirmed using mannose inhibition assay....

Research Article
Published On: February 14, 2018

A Systematic Analysis of 314 Cases of Adverse Drug Reactions to Acanthopanax Injection

Yuhe G1†, Junbin Z1†, Xiaojun Z2†, Huiyan W1, Xueting L1 and Ailin T1*
Background: Acanthopanax has been successfully administered for the treatment of many diseases, however, adverse drug reactions (ADRs) occur frequently. Objectives: To probe the full profile and underlying basis for ADRs to Acanthopanax injection. Methods: All related medical articles published from 1979-2012 were searched online using Acanthopanax injection keywords....

Case Report
Published On: April 30, 2018

Angioimmunoblastic T Cell Lymphoma: Typical Presentation of an Atypical Disease

Mohanty A, Majhi M, Sahu PK, Panchari PK, Dinakar Y and Satpathi S*
Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon T-cell type of non-Hodgkin lymphoma. Its clinical manifestations are typical of lymphoma, and may include maculopapular...

Published On: July 16, 2018

Impact of Chronically Ongoing Infections - HHV-6 and HHV-7 on the Course of Various Diseases

Viksna L*
The spectrum and dynamics of infectious diseases have changed significantly over the last decades, with the increase in the number of chronic infections...