Implementing a Quality by Design Approach in Chromatographic Determination of Some Antidiabetic Drugs
Ahmed RM1*, Ibrahim A2, El-Gendy AE1 and Hadad GM3
This article aims to explain the steps for application of quality by design (QbD) concept to analytical method development and validation, by using an example of simultaneous determination of four antidiabetic drugs (Metformin HCl, Vildagliptin, Sitagliptin phosphate mono hydrate and Pioglitazone HCl) in its pharmaceutical dosage form by RP-HPLC. By using QbD tools, enable earlier understanding and identification of variables...
Quantitative Analysis of Flavonoids of Hylocereus undatus (Bawanghua)
Yan Yi1, Ying Wang2, Song-Lin Li3, Wen-Cai Ye2 and Qing-Wen Zhang1*
Bawanghua, the flower of Hylocereus undatus, is an edible herb. Quercetin, kaempferol and isorhamnetin glycosides are the major components in Bawanghua. The major flavonoid glycosides in Bawanghua are too identical to be separated in preparative scale which hindered the using of those glycosides as references in routine quality control method. Quantification of the flavonoid aglycones hydrolyzed from their glycosides...
Dalfampridine: A Bioactive Compound for Improvement in Patients with Multiple Sclerosis
Multiple sclerosis (MS) is known as chronic autoimmune, inflammatory neurological disorder of the central nervous system which may cause progressive walking impairment which results to disability, loss of independence and diminished quality of life. Dalfampridine (4-aminopyridine), a voltagedependent potassium channel blocker, has been shown to improve walking in patients with MS, as demonstrated by an increase...
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