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Research Article

Implementing a Quality by Design Approach in Chromatographic Determination of Some Antidiabetic Drugs

Ahmed RM1*, Ibrahim A2, El-Gendy AE1 and Hadad GM3
This article aims to explain the steps for application of quality by design (QbD) concept to analytical method development and validation, by using an example of simultaneous determination of four antidiabetic drugs (Metformin HCl, Vildagliptin, Sitagliptin phosphate mono hydrate and Pioglitazone HCl) in its pharmaceutical dosage form by RP-HPLC. By using QbD tools, enable earlier understanding and identification of variables...

Research Article

The Effects of Lead, Cadmium, Mercury and Arsenic on Fish and Seawater in Red Sea and the Gulf of Aden at Three Different Locations in Yemen

Al-qadasy MKO1, Babaqi AS1, Al-Abyadh MM2* and Al-kaf AG3
This study investigate concentrations of heavy metals (Pb, Cd, Hg and As) in water and muscle fish,collected from three different sites (Aden, Al-Hodeidah and AL-Mukalla) of the Red Sea and the Gulf of Aden in Yemen’s coastal. Fresh samples were purchased from near the sea public auction site locations. The four species of fish (emperor) Lethrinus mahsena, (Longtail tuna)...

Research Article

Quantitative Analysis of Flavonoids of Hylocereus undatus (Bawanghua)

Yan Yi1, Ying Wang2, Song-Lin Li3, Wen-Cai Ye2 and Qing-Wen Zhang1*
Bawanghua, the flower of Hylocereus undatus, is an edible herb. Quercetin, kaempferol and isorhamnetin glycosides are the major components in Bawanghua. The major flavonoid glycosides in Bawanghua are too identical to be separated in preparative scale which hindered the using of those glycosides as references in routine quality control method. Quantification of the flavonoid aglycones hydrolyzed from their glycosides...

Research Article

Molecular Docking Studies and Insilico ADMET Screening of Some Novel Chalcone Substituted 9-Anilinoacridines as Topoisomerase II Inhibitors

Kalirajan R*, Pandiselvi M, Sankar S and Gowramma B
9-anilinoacridine derivatives are inhibiting DNA topoisomerase II (topoII) due to the ability of acridine nucleus to intercalate into DNA base pair. In this study, the identification of potential ligands from chalcone substituted 9-anilinoacridines targeted against topoisomerase-II (1ZXM) by molecular modelling and docking studies using Schrodinger suit-2013 Maestro 9.3 version. Insilco ADMET screening also performed by...

Mini Review

Dalfampridine: A Bioactive Compound for Improvement in Patients with Multiple Sclerosis

Sahu JK1* and Mishra A2
Multiple sclerosis (MS) is known as chronic autoimmune, inflammatory neurological disorder of the central nervous system which may cause progressive walking impairment which results to disability, loss of independence and diminished quality of life. Dalfampridine (4-aminopyridine), a voltagedependent potassium channel blocker, has been shown to improve walking in patients with MS, as demonstrated by an increase...

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