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Volume - 3 Edition - 1

Review Article
Published On: February 3, 2020

Aromatic Substitution Reactions: An Overview

Kapoor Y and Kumar K*
The introduction or replacement of substituent’s on aromatic rings by substitution reactions is one of the most fundamental transformations in organic chemistry. On the basis of the reaction mechanism, these substitution reactions can be divided into electrophilic, nucleophilic...

Research Article
Published On: July 2, 2020

A Novel Development of Cyclic Tetrapeptide as an EGFR Tyrosine Kinase Inhibitor Assayed by ELISA Experiment and Docking Study

Akaho E*
The first purpose of this project is to synthesize innovative cyclic peptides and test them as Epidermal Growth Factor Tyrosine Kinase Inhibitor (EGFR-TKI) by Enzyme-Linked Immuno Sorbent Assay (ELISA) experiment. The Cyclic Phe-Phe-Phe-Gly Tetrapeptide (CPTP) exhibited a strong IC50 of 55.6 nM while cyclic heptapeptides, μM level. The second purpose is to compare...