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Volume - 1 Edition - 1 (Jan - Mar)

Research Article
Published On: January 26, 2018

Implementing a Quality by Design Approach in Chromatographic Determination of Some Antidiabetic Drugs

Ahmed RM1*, Ibrahim A2, El-Gendy AE1 and Hadad GM3
This article aims to explain the steps for application of quality by design (QbD) concept to analytical method development and validation, by using an example of simultaneous determination of four antidiabetic drugs (Metformin HCl, Vildagliptin, Sitagliptin phosphate mono hydrate and Pioglitazone HCl) in its pharmaceutical dosage form by RP-HPLC. By using QbD tools, enable earlier understanding and identification of variables...

Research Article
Published On: January 26, 2018

The Effects of Lead, Cadmium, Mercury and Arsenic on Fish and Seawater in Red Sea and the Gulf of Aden at Three Different Locations in Yemen

Al-qadasy MKO1, Babaqi AS1, Al-Abyadh MM2* and Al-kaf AG3
This study investigate concentrations of heavy metals (Pb, Cd, Hg and As) in water and muscle fish,collected from three different sites (Aden, Al-Hodeidah and AL-Mukalla) of the Red Sea and the Gulf of Aden in Yemen’s coastal. Fresh samples were purchased from near the sea public auction site locations. The four species of fish (emperor) Lethrinus mahsena, (Longtail tuna)...

Research Article
Published On: January 26, 2018

Quantitative Analysis of Flavonoids of Hylocereus undatus (Bawanghua)

Yan Yi1, Ying Wang2, Song-Lin Li3, Wen-Cai Ye2 and Qing-Wen Zhang1*
Bawanghua, the flower of Hylocereus undatus, is an edible herb. Quercetin, kaempferol and isorhamnetin glycosides are the major components in Bawanghua. The major flavonoid glycosides in Bawanghua are too identical to be separated in preparative scale which hindered the using of those glycosides as references in routine quality control method. Quantification of the flavonoid aglycones hydrolyzed from their glycosides...

Research Article
Published On: January 26, 2018

Molecular Docking Studies and Insilico ADMET Screening of Some Novel Chalcone Substituted 9-Anilinoacridines as Topoisomerase II Inhibitors

Kalirajan R*, Pandiselvi M, Sankar S and Gowramma B
9-anilinoacridine derivatives are inhibiting DNA topoisomerase II (topoII) due to the ability of acridine nucleus to intercalate into DNA base pair. In this study, the identification of potential ligands from chalcone substituted 9-anilinoacridines targeted against topoisomerase-II (1ZXM) by molecular modelling and docking studies using Schrodinger suit-2013 Maestro 9.3 version. Insilco ADMET screening also performed by...

Mini Review
Published On: January 26, 2018

Dalfampridine: A Bioactive Compound for Improvement in Patients with Multiple Sclerosis

Sahu JK1* and Mishra A2
Multiple sclerosis (MS) is known as chronic autoimmune, inflammatory neurological disorder of the central nervous system which may cause progressive walking impairment which results to disability, loss of independence and diminished quality of life. Dalfampridine (4-aminopyridine), a voltagedependent potassium channel blocker, has been shown to improve walking in patients with MS, as demonstrated by an increase...

Mini Review
Published On: February 7, 2018

Alternative Approach in Pharmacological Research

Loh YC1*, Tan CS1 and Omar WMW2*
The present review aims to suggest an alternative approach to pharmacological research. That is,the use of traditional Chinese medicine, which could potentially solves the major problems faced by global scientists in recent years especially to overcome the relatively low...

Research Article
Published On: February 8, 2018

Determination of Sugammadex in Human Plasma using Protein Precipitation and Ultra High Performance Liquid Chromatography/Tandem Mass Spectrometry

Zeng W*, Xu Y, Constanzer ML, Goykhman D and Woolf EJ
A simple LC-MS/MS method for the quantification of sugammadex in human plasma is described. Samples were prepared using protein precipitation with acetonitrile containing 0.37% hydrochloric acid as precipitator and Waters Ostra plate for protein and phospholipid removal....

Review Article
Published On: February 7, 2018

CAR T Cell: A Novel Treatment Regime for Cancer

Kapoor Y1, Dubey S1, Kar S2 and Kumar K1*
Cancer is always being a matter of concern and when it comes to its treatment Chimeric antigen receptor (CAR) T cell therapy is an approaching and is found to be a promising cancer treatment. In this review, we focus on the production and design of CAR T cell...

Research Article
Published On: April 13, 2018

Green Synthesis of Pyran Derivatives Using Lemon Peel Powder as a Natural Catalyst and their Antimicrobial Activity

Khandare PM, Ingle RD, Tekale SU, Jadhav AS, Mashele S, Kendrekar PS* and Pawar RP*
A simple and green one pot protocol for the synthesis of bioactive pyran annulated heterocyclic compounds at room temperature in ethanol has been developed using lemon peel powder as a catalyst....

Research Article
Published On: April 18, 2018

Polysaccharide Absorbents in Moisture Activated Dry Granulation

Ochoa-Andrade AT*, Fierro MV, Bauzán ML, Origoni MX and Trezza VM
The aim of the present work was to study the hydrogel-forming polysaccharides carrageenan, guar and xanthan gum as potential absorbents in moisture activated dry granulation (MADG). Preferences of formulators regarding absorbents tend to incline towards microcrystalline cellulose...

Research Article
Published On: April 30, 2018

Aescin as Novel Green Analytical Reagent for Optimization, Validation and Application of Spectrophotometric Method for Determination of Nitrite in Drinking and Environmental Water Samples

Al-Okab RA*, Abdul Galil MS and Amanyabdouh
Replacement of toxic reagents was established to attain the standards of clean chemistry. Novel green reagent for simple and highly sensitive spectrophotometric determination of trace amounts of...

Research Article
Published On: May 11, 2018

Micellar Liquid Chromatography Coupled with Fluorimetric Detection for the Determination of Terbinafine in Dosage Forms and Plasma

Belal F, Sharaf El-Din MK, Eid MI and El-Gamal RM*
A newly developed micellar liquid chromatographic analysis technique was utilized for the determination of Terbinafine HCl (TRH). A 150mm x 4.6mm i.d. Shim-pack Cyanopropyl-bonded...