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Essential Thrombocythemia Characterization: Mutational, Cytokine, and Thrombotic Profiling

Authors: Hernandez-Matias L, Maysonet-Cruz J, Calzada-Jorge N, Pérez-Donato L, Torres Rivera W, Ramírez-Rodríguez J, Laureano-Torres F, Méndez LB, Ríos O, Menéndez-Pérez J, Washington AV^* and Hunter-Mellado R

Abstract: Essential Thrombocythemia (ET) is characterized by a persistent thrombocytosis associated with mutations in Janus Kinase 2 (JAK2V617F), Myeloproliferative Leukemia protein (MPL), and/ or Calreticulin (CALR). Although ET mutational background has been defined for some