Search Sentinel Lymph Node in Melanoma: SPECT/CT,Added Value. A Case Report
Mangano AM1, Addabbo W2, Semprebene A1, Ventroni G1 and Mango L1*
The clinical case deals with a patient who after removal of a pigmented and ulcerated skin lesion obtains histopathological diagnosis of skin melanoma with dermal infiltration for a thickness of, 6mm and with Breslow level IV. The location of the primitive tumor was at the right inguinal region, more precisely in the overlap region. In the search for the sentinel lymph node essential for proper, staging of the...
The Retinoblastoma Binding Protein 6 Family is Essential for Embryonic Development and Carcinogenesis
Ntwasa M1*, Nweke E2 and Cajee UF2
Regulators of the tumour suppressor protein, p53 are promising anti-cancer drug candidates.The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, has emerged as an important player in carcinogenesis and is essential for both invertebrate and vertebrate embryonic development. It is a multi-domain protein associated with key cellular processes such as cell cycle control and apoptosis...
Vitamin D and Prevention of Breast Cancer
Takalkar UV1*, Asegaonkar SB2 and Advani S3
Apart from classical actions of vitamin D on bone and mineral metabolism, it exerts diverse protective biological effects against carcinogenesis. Vitamin D may play role in controlling growth of normal breast cells and may help in prevention of growth of malignant mammary cells. Hypovitaminosis D is gaining attention as an emerging risk factor of breast cancer. Some ecological studies suggest association of...
Breast Cancer: Forecasting an Evolving Ecosystem
Gacche RN1* and Kamble S2
Advances in gene-expression profiling and parallel sequencing technology in the past two decades resulted in unravelling the pathophysiological molecular signatures in the progression of cancer in general and breast cancer in particular. In the current state of the art it has been well established that cancer cells within a single tumor are not alike at genetic morphological and behavioral levels. Neverthe...
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