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Volume - 1 Edition - 1 (Jan - Mar)

Case Report
Published On: January 26, 2018

Search Sentinel Lymph Node in Melanoma: SPECT/CT,Added Value. A Case Report

Mangano AM1, Addabbo W2, Semprebene A1, Ventroni G1 and Mango L1*
The clinical case deals with a patient who after removal of a pigmented and ulcerated skin lesion obtains histopathological diagnosis of skin melanoma with dermal infiltration for a thickness of, 6mm and with Breslow level IV. The location of the primitive tumor was at the right inguinal region, more precisely in the overlap region. In the search for the sentinel lymph node essential for proper, staging of the...

Mini Review
Published On: January 26, 2018

The Retinoblastoma Binding Protein 6 Family is Essential for Embryonic Development and Carcinogenesis

Ntwasa M1*, Nweke E2 and Cajee UF2
Regulators of the tumour suppressor protein, p53 are promising anti-cancer drug candidates.The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, has emerged as an important player in carcinogenesis and is essential for both invertebrate and vertebrate embryonic development. It is a multi-domain protein associated with key cellular processes such as cell cycle control and apoptosis...

Mini Review
Published On: January 26, 2018

Vitamin D and Prevention of Breast Cancer

Takalkar UV1*, Asegaonkar SB2 and Advani S3
Apart from classical actions of vitamin D on bone and mineral metabolism, it exerts diverse protective biological effects against carcinogenesis. Vitamin D may play role in controlling growth of normal breast cells and may help in prevention of growth of malignant mammary cells. Hypovitaminosis D is gaining attention as an emerging risk factor of breast cancer. Some ecological studies suggest association of...

Research Article
Published On: February 8, 2018

Correlation of Various Prognostic Parameters with Human Epidermal Growth Factor Receptor-2/Neu Status in Malignant Breast Lesions

Swati Sucharita Mohanty1*, Prafulla Kumar Mohanty1, Sumit Subhadarshi Mohanty2, Padmalaya Thakur3, Surabhi4
The incidence of breast cancer is although low in India, but is rising. Breast cancer is the commonest cancer of urban Indian women and the second commonest in the rural women. Amplification or overexpression of Human Epidermal Growth Factor Receptor-2/neu (HER-2/neu) oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer....

Mini Review
Published On: February 9, 2018

Breast Cancer: Forecasting an Evolving Ecosystem

Gacche RN1* and Kamble S2
Advances in gene-expression profiling and parallel sequencing technology in the past two decades resulted in unravelling the pathophysiological molecular signatures in the progression of cancer in general and breast cancer in particular. In the current state of the art it has been well established that cancer cells within a single tumor are not alike at genetic morphological and behavioral levels. Neverthe...

Editorial
Published On: February 27, 2018

Inhibitors of PI3K/AKT/mTOR Signaling Pathway as a Novel Targeted Therapy for Cancer

Thekkuttuparambil Ananthanarayanan Ajith*
There are various cytoplasmic cross talking signaling pathways possible in the target cell. The phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway (PI3K/AKT/mTOR pathway) plays a pivotal role in the pathophysiology of cancer. mTOR is a serine/threonine protein kinase involve in the downstream of the PI3K signaling pathway...

Research Article
Published On: March 19, 2018

Breast Lipomodelling Outcome Following Conservative Breast Cancer Surgery and Reconstructive Surgery in a District Hospital

Metry M*, Shaaban M, Edgar B, Youssef M, Mclean N, Carr M and Sierra P
Lipomodelling has been increasingly used recently for the correction of defects and asymmetry following oncologic breast cancer treatment [1]. Current evidence on the efficacy of breast reconstruction using lipomodelling after breast cancer treatment is inadequate...

Editorial
Published On: March 30, 2018

Physical Activity Promotion for Cancer Prevention

Mauro De Santi*
Physical activity is known to reduce all-cause mortality [1], and individuals who maintain a lifestyle with high mobility and physical activity appear to have a remarkably lower risk of noncommunicable diseases, including cancer. In fact, leisure-time physical activity is associated with lower risks of the primary development of many cancer types....

Editorial
Published On: April 16, 2018

Head and Neck Squamous Cell Carcinoma in Pediatric Population

Lakshmi Shree Mahadevan*
Head and neck Squamous cell carcinoma (HNSCC) is a disease of the elderly associated with tobacco, alcohol consumption. Of late there is increased incidence in the younger age group with Human Papilloma virus being the most common causative agent [1]. HNSCC is rarity in the population cohort of less than 20 years....

Case Report
Published On: April 16, 2018

Pleomorphic Adenoma of the Hard Palate: Case Report

Vuletić M, Kuna T, Bušić Nj and Gabrić D4*
Pleomorphic adenoma (PA), or benign mixed tumor, is the most common salivary neoplasm. Most common intraoral location is the palate (specifically, the junction of the soft and hard palates), followed by upper lip, buccal mucosa, floor of the mouth, tongue, tonsil, pharynx, and retromolar area....